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射频联合透明质酸填充剂用于皮肤年轻化的疗效、寿命和安全性

The Efficacy, Longevity, and Safety of Combined

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【 文献重点摘要 】
 

Background: Recent advances in hyaluronic acid (HA) fillers and radiofrequency (RF) devices have been made in the context of skin rejuvenation and cosmetic surgery. Moreover, combination regimens with both techniques are currently being developed.

 

Objective: The present study was designed to examine the clinical and histologic effects of a new needle that incorporates an RF device for HA injections.

 

Methods: A new intradermal needle RF device (INNOfill; Pacific Pharma, Korea) was assessed in the present study. In the animal arm, procollagen production was measured by using enzyme-linked immunosorbent assay, the filler volume was quantified by incorporating a dye with filler, and the filler distribution was assessed through the changes in tissue structure. In the human arm, the efficacy of the combination regimen was assessed by using the wrinkle severity rating scale (WSRS).

 

Results: In the animal study, RF treatment increased procollagen production in a time-dependent fashion. The total volume was significantly increased with the RF treatment when compared with the filler injections alone, and lasted for up to 7 weeks after treatment. Additionally, the filler distribution was reduced in animals treated with RF when compared with the untreated group. In the human study, the nasolabial folds of subjects treated with RF before filler injections exhibited a significantly greater change in the WSRS score from baseline when compared with the nasolabial folds treated with filler injections alone.

 

Conclusion: A new device incorporating RF treatment before HA filler injection may represent a biocompatible and long-lasting advance in skin rejuvenation.

 

Keywords: Filler, Radiofrequency, Skin rejuvenation

 

背景:透明质酸(HA)填充物和射频(RF)装置在皮肤年轻化和整容手术方面取得了最新进展。此外,目前正在开发两种技术的联合方案。

 

目的:本研究旨在检测一种新型针头的临床和组织学效果,该针头结合射频设备用于HA注射。

 

方法:本研究对一种新的皮内针状射频装置(INNOfill,Pacific Pharma,Korea)进行了评估。用酶联免疫吸附法测定前胶原产量,用染料掺入填料定量填充物的体积,通过组织结构的变化评价填充物的分布。在人类手臂上,使用皱纹严重程度评定量表(WSRS)评估联合方案的疗效。

 

结果:在动物研究中,RF治疗以时间依赖的方式增加前胶原的产生。与单独注射填料相比,射频治疗的总体积显著增加,并持续到治疗后的7周。此外,与未处理组相比,RF处理组的填充物分布减少。在人体研究中,与仅使用填充物注射的鼻唇沟相比,在填充注射前接受RF治疗的受试者的WSRS评分较基线有显著的变化。

 

结论:在HA填充剂注射前结合射频治疗的新装置可能代表着皮肤年轻化方面的生物相容性和长期进步。

 

关键词:填充剂,射频,皮肤年轻化

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