【 文献重点摘要 】

Data demonstrating the efficacy of hyaluronic acid (HA)-based mesotherapy for skin rejuvenation are scarce. The aim of the study is to assess the efficacy of non-reticulated HA-based mesotherapy on skin elasticity and complexion radiance. 55 women with cutaneous ageing signs included in the Full Analysis Set (FAS) population blindly received intradermal micro-injections (50 x 0.02 mL) of non-cross-linked HA filler with mannitol (Glytone 1, HA concentration: 14 mg/g) in one cheek and saline physiological solution in the other according to hemifacial randomisation in 3 monthly sessions. Elasticity (E1 and E2 stiffness parameters) and dermis thickness were measured by cutometry and 20 MHz echography, before (D0) treatment and 1 (1M) and 3 months (3M) after the last injection. A trained panel blindly scored skin complexion radiance from standardised and calibrated photographs, using 100 mm analogue scales. In the FAS population, only HA filler significantly decreased E1 at 1M (-10.9 %, p = 0.026) and 3M (-10.5 %, p = 0.035) compared with D0; its effect versus the control tended to be more persistent, with a difference between treatments at 3M close to significance (p = 0.063). E2 also decreased at 1M (-8.2 %, p = 0.027 in the per protocol population, n = 53) and 3M after HA-treatment only. Dermis thickness significantly increased after HA-treatment at 1M (+3.4 %, p = 0.028) and 3M (+4 % , p = 0.008), and after control-treatment at 1M only (+2.5 %, p = 0.015). The HA filler significantly improved complexion radiance at 3M compared with the control (p = 0.012) and for 51 % of subjects, their skin status. Non-reticulated HA-based mesotherapy significantly and sustainably improves skin elasticity and complexion radiance.

Keywords

Mesotherapy, Hyaluronic acid, Dermis thickness, Micro-injection

证明透明质酸(HA)为基础的中胚层疗法对皮肤嫩肤的有效性的数据很少。本研究的目的是评估非网状透明质酸中胚层疗法对皮肤弹性和肤色光泽的疗效。55名有皮肤老化体征的女性纳入全分析组(FAS)人群，按半面部随机抽样方法，一侧面颊皮内注射非交联型HA填充剂(50×0.02mL)，一侧面颊注射甘露醇(甘露醇1，HA浓度：14 mg/g)，另一侧皮内注射生理盐水，疗程为3个月。分别于治疗前(D0)、最后一次注射后1个月(1个月)和3个月(3个月)用皮肤计和20 MHz超声测量弹性(E1和E2刚度参数)和真皮厚度。一个训练有素的小组使用100毫米的模拟刻度，从标准化和校准的照片中盲目地给皮肤肤色照度打分。在FAS群体中，与D0相比，仅HA填料在1M(-10.9%，p=0.026)和3M(-10.5%，p=0.035)时显著降低E1，其作用与对照组相比更持久，在3M时处理间差异接近显著(p=0.063)。仅HA治疗后，E2在1M(-8.2%，p=0.027，n=53)和3M时也降低了。真皮厚度在1M(+3.4%，p=0.028)和3M(+4%，p=0.008)处显著增加，而对照组仅在1m处(+2.5%，p=0.015)。与对照组(p=0.012)和51%的受试者相比，透明质酸填充剂显著改善了3M时的肤色亮度，改善了他们的皮肤状况。基于非网状HA的中胚层疗法显著且可持续地改善皮肤弹性和肤色光泽。

关键词

中胚层疗法，透明质酸，真皮厚度，微量注射