【 文献重点摘要 】

Background

Granuloma annulare is a benign inflammatory disease of the skin. The etiology and pathogenesis of the disease are not yet determined, but some authors have proposed that it might be associated with a variety of underlying conditions such as thyroid disorders, diabetes mellitus and positive tuberculin skin test.

Objective

This study was conducted to find the probable relationship between granuloma annulare and diabetes mellitus, thyroid disorders and positive tuberculin skin test.

Patients and methods

A total of 28 patients with granuloma annulare were recruited from our dermatology outpatient clinic, and data on sex, age and distribution of granuloma annulare lesions were collected. Forty-one age- and sex-matched apparently healthy volunteers serving as controls were also included. Thyroid stimulating hormone (TSH), fasting blood sugar (FBS) and tuberculin skin tests were performed for both groups.

Results

Mean serum level of FBS in the patient group was significantly higher than the mean serum level of FBS in the control group (110.60±46.31 mg/dL versus 88.39±10.58 mg/dL, respectively, p=0.004). Mean serum level of TSH in the patient group was 3.43±2.73 mIU/L, which was not significantly different from the mean serum level of TSH in the control group (3.26±2.11 mIU/L, p=0.772). Four individuals in the patient group and only 1 in the control group had a positive tuberculin skin test.

Conclusion

Granuloma annulare patients are better to be assessed for diabetes mellitus, but the relationship between this skin disease and thyroid disorders or tuberculin skin test still needs to be investigated.

Keywords

granuloma annulare, thyroid, diabetes mellitus, tuberculin skin test

背景

环状肉芽肿是一种良性的皮肤炎症性疾病。该病的病因和发病机制尚未确定，但一些作者提出，它可能与各种潜在的疾病有关，如甲状腺疾病、糖尿病和结核菌素皮肤试验阳性。

目的

探讨环状肉芽肿与糖尿病、甲状腺疾病及结核菌素皮试阳性的可能关系。

患者与方法

收集我院皮肤科门诊就诊的28例环状肉芽肿患者的性别、年龄及环状肉芽肿皮损分布情况。41名年龄和性别相匹配的明显健康的志愿者也被包括在内，作为对照。两组均进行促甲状腺激素(TSH)、空腹血糖(FBS)和结核菌素皮试。

结果

患者组空腹血糖均值(110.60±46.31 mg/dL)明显高于对照组(88.39±10.58 mg/dL，P=0.004)。患者组血清促甲状腺激素平均水平为3.43±2.73mIU/L，与对照组(3.26±2.11mIU/L)比较差异无统计学意义(p=0.772)。患者组有4人，对照组只有1人结核菌素皮肤试验呈阳性。

结论

环状肉芽肿更适合于糖尿病的评估，但该皮肤病与甲状腺疾病或结核菌素皮试的关系尚需进一步研究。

关键词

环状肉芽肿，甲状腺，糖尿病，结核菌素皮肤试验