- 4326人
- 分享收藏
A Case of Mycobacterial Skin Disease Caused by Mycobacterium peregrinum, and a Review of Cutaneous
Fuminao Kamijo
简介
【 文献重点摘要 】
An 83-year-old Japanese man presented with a 2-month history of symptomatic nodules on the left hand. He was not in an immunocompromised condition and reported no causal events. A biopsy specimen demonstrated granulomatous tissue with mixed cell infiltration consisting of neutrophils, histiocytes, lymphocytes, and multinuclear giant cells. No bacillus was detected by PAS, acid-fast stain, immunofluorescent stain or polymerase chain reaction analysis. The isolate was found to be a rapidly growing mycobacterium after 4 weeks of incubation at 25°C on an Ogawa egg slant. Mycobacterium peregrinum was isolated by DNADNA hybridization analysis, 16S rRNA gene sequence, and by its production of 3-day arylsulfatase. The patient received 200 mg oral minocycline for 28 weeks. The lesion disappeared after 10 weeks of this treatment.
一位83岁的日本男子在左手有2个月的症状性结节病史。他没有免疫功能受损的情况，也没有报告任何因果事件。活检标本显示肉芽肿组织混合细胞浸润，由中性粒细胞、组织细胞、淋巴细胞和多核巨细胞组成。PAS、抗酸染色、免疫荧光染色及聚合酶链反应分析均未检出芽孢杆菌。经25°C培养4周后，发现该分离株是一株生长迅速的分枝杆菌。通过DNA杂交分析、16S rRNA基因序列测定和3天芳基硫酸酯酶产生法分离出游离型分枝杆菌。患者口服米诺环素200 mg，疗程28周。经过10周的治疗，病灶消失了。
学习目录
学员评价
DMCAS学习顾问
资料研究员
