首页 / 国际医美文献/ 肉毒素 / 【肉毒素文献】A型肉毒毒素治疗Morton神经瘤
  • 3466人
  • 分享
    收藏

【肉毒素文献】A型肉毒毒素治疗Morton神经瘤

Treatment of Morton Neuroma with Botulinum Toxin A

价格 19.90
学习有效期 长期有效

简介

【 文献重点摘要 】
 

Background and Objective

Morton neuroma is a common cause of metatarsalgia of neuropathic origin. Systematic reviews suggest that insufficient studies have been performed on the efficacy of the different treatments available. OnabotulinumtoxinA has shown a degree of usefulness in other conditions associated with neuropathic pain. The aim of this study was to investigate the therapeutic potential of onabotulinumtoxinA in Morton neuroma.

 

Patients and Methods

We present an open-label, pilot study with 17 consecutive patients with Morton neuroma and pain of more than 3 months’ duration that had not responded to conservative treatment with physical measures or corticosteroid injection. Patients received one onabotulinumtoxinA injection in the area of the neuroma. The main outcome measure was the variation in the pain on walking evaluated using a visual analogue scale (VAS) before treatment and at 1 and 3 months after treatment. The secondary outcome was the change in foot function, which was assessed using the Foot Health Status Questionnaire. Results In the overall group, the mean initial VAS score on walking was 7. This mean score had fallen to 4.8 at 1 month after treatment and to 3.7 at 3 months. Twelve patients (70.6 %) reported an improvement in their pain and five patients (29.4 %) reported no change; exacerbation of the pain did not occur in any patient. Improvements were also observed in two of the dimensions of the Foot Health Status Questionnaire: foot pain, which improved from a mean of 38.88 before treatment to 57 at 3 months, and foot function, which improved from a mean of 42.27 before treatment to 59.9 at 3 months. Clinical variables including age, sex, site and size of the lesion, standing activity, weekly duration of walking, footwear, foot type and footprint had no influence on the outcome. No adverse effects were reported.

 

Conclusions

In this pilot study, injection with onabotulinumtoxinA was shown to be of possible usefulness to relieve the pain and improve function in Morton neuroma. This finding opens the door to further clinical research.

 

背景与目的

Morton神经瘤是神经源性跖痛的常见病因。系统评价表明,对现有不同治疗方法的疗效研究不足。OnabotulinumoxinA在其他与神经病理性疼痛相关的情况下显示出一定程度的有效性。本研究的目的是探讨奥纳博林毒素A对Morton神经瘤的治疗潜力。

 

患者和方法

我们提出了一项开放标签的先导性研究,对17名连续3个月以上的Morton神经瘤和疼痛患者进行研究,这些患者对采用物理措施或注射皮质类固醇的保守治疗没有反应。患者在神经瘤区域接受了一次奥纳博林毒素A注射。主要观察指标为治疗前、治疗后1个月和3个月时用视觉模拟评分(VAS)评定行走疼痛的变化。次要结果是足部功能的改变,这是使用足部健康状况问卷进行评估的。结果治疗后1个月VAS评分降至4.8分,3个月VAS评分降至3.7分,平均步行VAS评分为7分。12名患者(70.6%)报告他们的疼痛有所改善,5名患者(29.4%)报告没有变化;任何患者都没有出现疼痛加剧。足部健康状况问卷的两个维度也有改善:足部疼痛,从治疗前的平均38.88分改善到3个月时的57分;足部功能,从治疗前的平均42.27分改善到3个月时的59.9分。临床变量包括年龄、性别、病变部位和大小、站立活动、每周步行时间、鞋类、足型和足迹对结果没有影响。没有不良反应的报道。

 

结论

在这项先导性研究中,注射奥纳博林毒素A可能对Morton神经瘤的疼痛缓解和功能改善有一定的作用。这一发现为进一步的临床研究打开了大门。

题库
暂无绑定的题库哦~

学习目录

学员评价

暂无评价哦~
授课老师

DMCAS学习顾问

资料研究员

猜你想学