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单次注射肉毒杆菌毒素后超过1年，大鼠肌肉大小恢复，但功能未恢复
Recovery of rat muscle size but not function
简介
【 文献重点摘要 】
Introduction
Neurotoxin injection is used to treat a wide variety of neuromuscular disorders. The purpose of this study was to measure the functional and structural properties of botulinum toxin–injected adult rat skeletal muscle over nearly the entire lifespan.
Methods
Ten groups of animals were subjected to either neurotoxin injection [Botox, Type A (BT -A); Allergan, Irvine, California] or saline solution injection. Neurotoxin-injected animals (n590) were analyzed at different time-points: 1 week; 1 month; 3 months; 6 months; 12 months; or 18 months.
Results
In spite of the recovery of structural features, such as muscle mass and fiber area, dorsiflexion torque production remained significantly depressed by 25%, even at 12 months after neurotoxin injection.
Discussion
The data demonstrate that, after a single BT -A injection, although gross muscle morphology recovered over a 12-month time period, loss of contractile function did not recover.
介绍
神经毒素注射用于治疗各种神经肌肉疾病。这项研究的目的是在几乎整个生命周期内测量注射肉毒杆菌毒素的成年大鼠骨骼肌的功能和结构特性。
方法
对10组动物进行神经毒素注射；Allergan，Irvine，California]或盐溶液注射。神经毒素注射动物(n590)在不同时间点进行分析:1周；1个月；3个月；6个月；12个月；或者18个月。
结果
尽管恢复了肌肉质量和纤维面积等结构特征，但背屈力矩的产生仍然显著降低了25%，甚至在注射神经毒素后的12个月。
讨论
数据表明，在单次注射牛血清白蛋白后，虽然总肌肉形态在12个月内恢复，但收缩功能的丧失并未恢复。
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