【 文献重点摘要 】
 

Background: Minimally invasive cosmetic procedures are the most commonly performed aesthetic techniques by plastic surgeons. Patients are interested in a pain-free experience. Surgeons desire patient satisfaction and time-efficient utilization of office staff and resources. Clinical evidence exists for use of vapocoolant technology to reduce pain associated with intravenous cannulation in the pediatric population and in hemodialysis patients. Applying vapocoolant technology to facial rejuvenation is a novel Approach to decrease pain associated with neurotoxin or filler injection.

Methods: A randomized, prospective study was conducted, testing 15 subjects receiving filler injections and another 15 patients receiving neurotoxin injections using a split-face model. The vapocoolant spray used was composed of a 95:5 ratio of 1,1,1,3,3-pentafluoropropane and 1,1,1,2-tetrafluoroethane. Within each group, individual patients randomly received injection (filler or neurotoxin) alone versus injection (filler or neurotoxin) plus vapocoolant on an equivalent half of his or her face. An independent examiner recorded from each patient on a scale of 1 to 10 perceived pain for injection alone versus injection plus vapocoolant spray. Results were calculated as a percentage change of pain scores experienced after injection for each person between the control (nonvapocoolant) and treatment (vapocoolant) sides of the face.

Results: Vapocoolant spray at the time of cosmetic facial injections leads to a 59% decrease in perceived pain score with neurotoxin injections (range, 0%-100% change) and 64% decrease in perceived pain score with filler injections (range, 0%-100% change). These results were statistically significant with P < .05.

Conclusion: Vapocoolant spray reduces pain associated with facial rejuvenation procedures.

背景：微创整形手术是整形外科医生最常用的美容技术。患者对无痛体验很感兴趣。外科医生希望患者满意，并能及时有效地利用办公室人员和资源。临床证据表明，在儿科人群和血液透析患者中，使用vapocoolant技术可以减少与静脉插管相关的疼痛。将vapocoolant技术应用于面部年轻化是减轻神经毒素或填充物注射引起的疼痛的一种新方法。

方法：进行一项随机的前瞻性研究，使用裂脸模型测试15名接受填充剂注射的受试者和另外15名接受神经毒素注射的患者。所使用的vapocoolant喷雾由1，1，1，3，3-五氟丙烷和1，1，1，2-四氟乙烷按95：5的比例组成。在每组中，个别患者随机接受单独注射(填充物或神经毒素)与注射(填充物或神经毒素)加vapocoolant在他或她相等的半张脸上的比较。一名独立的检查员记录了每个患者的感觉疼痛，评分从1到10分，分别为单独注射和注射加vapocoolant喷雾。结果是根据注射后每个人面部对照侧(非vapocoolant)和治疗侧(vapocoolant)之间的疼痛评分的百分比变化来计算的。

结果：面部美容注射时的vapocoolant喷雾导致注射神经毒素时的知觉疼痛评分下降59%(变化幅度为0%~100%)，而注射填充物时的知觉疼痛评分下降64%(变化幅度为0%~100%)。这些结果具有统计学意义，P < .05。

结论：vapocoolant喷雾可减轻面部年轻化过程中的疼痛。