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Effects of Dimethylaminoethanol and Compound Amino Acid on D-Galactose
简介
【 文献重点摘要 】
A lasting dream of human beings is to reverse or postpone aging. In this study, dimethylaminoethanol (DMAE) and compound amino acid (AA) in Mesotherapy were investigated for their potential antiaging effects on D-galactose induced aging skin. At 18 days after D-gal induction, each rat was treated with intradermal microinjection of saline, AA, 0.1% DMAE, 0.2% DMAE, 0.1% DMAE + AA, or 0.2% DMAE + AA, respectively. At 42 days after treatment, the skin wound was harvested and assayed. Measurement of epidermal and dermal thickness in 0.1% DMAE + AA and 0.2% DMAE + AA groups appeared significantly thicker than aging control rats. No differences were found in tissue water content among groups. Hydroxyproline in 0.1% DMAE + AA, 0.2% DMAE + AA, and sham control groups was much higher than all other groups. Collagen type I, type III, and MMP-1 expression was highly upregulated in both 0.1% DMAE + AA and 0.2% DMAE + AA groups compared with aging control. In contrast, TIMP-1 expression levels of various aging groups were significantly reduced when compared to sham control. Coinjection of DMAE and AA into target tissue has marked antiaging effects on D-galactose induced skin aging model of rat.
逆转或延缓衰老是人类永恒的梦想。本研究探讨了二甲氨基乙醇(DMAE)和复合氨基酸(AA)在D-半乳糖诱导的皮肤衰老中的抗衰老作用。诱导后18d分别皮内注射生理盐水、AA、0.1%DMAE、0.2%DMAE、0.1%DMAE+AA、0.2%DMAE+AA。治疗后42d，取皮肤创面进行组织学检查。0.1%DMAE+AA组和0.2%DMAE+AA组大鼠表皮和真皮厚度明显高于衰老对照组。各组间组织含水量无明显差异。0.1%DMAE+AA组、0.2%DMAE+AA组和假手术对照组的羟脯氨酸含量明显高于其他各组。与衰老对照组相比，0.1%DMAE+AA组和0.2%DMAE+AA组I型、III型胶原和MMP-1表达均显著上调。相反，与假手术对照组相比，各老年组TIMP-1的表达水平显著降低。靶组织联合注射DMAE和AA对D-半乳糖诱导的大鼠皮肤衰老有明显的延缓作用。
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