【 文献重点摘要 】

Background

Platelet-rich plasma (PRP) is an autologous concentration of human platelets contained in a small volume of plasma and has recently been shown to accelerate rejuvenate aging skin by various growth factors and cell adhesion molecules.

Objective

This study was conducted to evaluate the efficacy and safety of intradermal injection of PRP in the human facial rejuvenation.

Methods

This study was a prospective, single-center, single-dose, open-label, non-randomized controlled clinical study. PRP injected to the upper site of this right infra-auricular area and all face. Saline was injected to the left infra-auricular area. Histopathological examinations were performed before PRP treatment, 28 days after the PRP, and saline (control) treatments.

Results

Twenty women ranging in age from 40 to 49 years (mean age, 43.65±2.43 years) were enrolled in the study. The mean optical densities (MODs) of collagen in the pre-treatment, control, and PRP-treated area were measured. They were 539±93.2, 787±134.15, 1,019±178, respectively. In the MOD of PRP, 89.05 percent improvement was found when MOD of PRP was compared with MOD of pre-treatment. The mean MOD of collagen fibers was clearly highest on the PRP side (p＜0.001). The PRP-to-saline improvement ratio (89.05% to 46.01%) was 1.93:1. No serious side effects were detected.

Conclusion

PRP increases dermal collagen levels not only by growth factors, but also by skin needling (the mesotherapy technique ‘point by point’). PRP application could be considered as an effective (even a single application) and safety procedure for facial skin rejuvenation.

Keywords

Collagen, Mesotherapy, Platelet-rich plasma, Skin needling, Skin rejuvenation

背景

富血小板血浆(PRP)是一种含有少量血浆的人血小板的自体浓度，最近被证明通过各种生长因子和细胞粘附分子加速皮肤衰老。

目的

评价PRP皮内注射用于面部年轻化的有效性和安全性。

方法

本研究为前瞻性、单中心、单剂量、开放标签、非随机对照临床研究。PRP注射到这个右耳下区的上部部位和所有面部。左耳下区注射生理盐水。分别在PRP治疗前、PRP治疗后28天和生理盐水(对照)治疗前进行组织病理学检查。

结果

本研究共入选20名女性，年龄40~49岁，平均(43.65±2.43)岁。测量预处理区、对照组和PRP处理区胶原的平均光密度(MODS)。分别为5 39±93 2、787±134.15、1 019±178。在PRP的MOD中，PRP的MOD与治疗前的MOD相比有89.05%的改善。PRP侧胶原纤维平均光密度值最高(P<0.001)。PRP与生理盐水的改善比(89.05%对46.01%)为1.93：1，未发现严重副作用。

结论

PRP不仅通过生长因子增加真皮胶原水平，而且还通过皮肤针刺(“逐点”的中胚层疗法)提高真皮胶原水平。PRP应用可以被认为是一种有效的(即使是单次应用)和安全的面部皮肤年轻化程序。

关键词

胶原蛋白、中胚层疗法、富血小板血浆、皮肤针刺、皮肤年轻化